Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss

作者：Jankauskas S S; Plotnikov E Y^*; Morosanova M A; Pevzner I B; Zorova L D; Skulachev V P; Zorov D B

来源：Biochemistry-Moscow, 2012, 77(6): 666-670.

DOI：10.1134/S0006297912060144

• kidney
• organ of Corti
• mitochondria
• antioxidant
• nephrotoxicity
• ototoxicity
• antibiotics

The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycininduced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.

• 出版日期2012-6