Morpholinosulfur Trifluoride (Morph-DAST)-Mediated Rearrangement in the Fluorination of Cyclic alpha,alpha-Dialkoxy Ketones toward 1,2-Dialkoxy-1,2-difluorinated Compounds

作者：Surmont Riccardo; Verniest Guido; De Groot Alex; Thuring Jan Willem; De Kimpe Norbert^*

来源：Advanced Synthesis & Catalysis, 2010, 352(16): 2751-2756.

DOI：10.1002/adsc.201000466

• deoxofluorination
• fluorine
• ketones
• piperidines
• rearrangement reactions

The deoxofluorination of cyclic alpha,alpha-dialkoxy ketones with morpholinosulfur trifluoride (Morph-DAST) resulted in 1,2-dialkoxy-1,2-difluorinated carbo-and heterocyclic compounds. The reaction proceeds via a 1,2-alkoxy migration leading to mixtures of cis- and trans-isomers.

• 出版日期2010-11-2