A SET/MYND chromatin re-modelling protein regulates Dictyostelium prespore patterning

作者：Nunez Corcuera Beatriz; Birch Joanna; Williams Jeffrey G^*

来源：International Journal of Developmental Biology, 2011, 55(2): 205-208.

DOI：10.1387/ijdb.113309bn

• Dictyostelium
• SET/MYND
• prespore
• cell sorting

SmdA is a Dictyosteliumorthologue of the SET/MYND chromatin re-modelling proteins. In developing structures derived from a null mutant for smdA (a smdA- strain), prestalk patterning is normal, but using a prespore lacZ reporter fusion, there is ectopic accumulation of beta-galactosidase in the prestalk region. As wild type slugs migrate, there is continual forward movement and redifferentiation of prespore cells into prestalk cells. Thus, a potential explanation for the ectopic reporter localization in smdA null prestalk cells is an increased rate of re-differentiation and anterior movement of prespore cells. In support of this notion, analysis of an unstable lacZ reporter, driven by the prespore promoter, reveals a normal staining pattern in the smdA- strain. We suggest that one or more genes regulated by SmdA acts to repress prespore re-specification.

• 出版日期2011