Development of a solvent selection guide for aldehyde-based direct reductive amination processes

作者:McGonagle Fiona I*; MacMillan Donna S; Murray Jane; Sneddon Helen F; Jamieson Craig; Watson Allan J B
来源:Green Chemistry, 2013, 15(5): 1159-1165.
DOI:10.1039/c3gc40359a

摘要

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

  • 出版日期2013