A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides

作者：Liu LB^*; Frohn M; Xi N; Dominguez C; Hungate R; Reider PJ

来源：Journal of Organic Chemistry, 2005, 70(24): 10135-10138.

DOI：10.1021/jo051640t

CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base, 8-hydroxy-quinoline as ligand, and H2O as cosolvent. Preliminary results with aryl chlorides are also reported.

• 出版日期2005-11-25