Association of HLA-DRB1*0405 with resistance to multibacillary leprosy in Taiwanese

作者：Hsieh Nan Kuang; Chu Chen Chung; Lee Nie Sue; Lee Hui Lin; Lin Marie^*

来源：Human Immunology, 2010, 71(7): 712-716.

DOI：10.1016/j.humimm.2010.03.007

• Human leukocyte antigen
• HLA-DRB1*0405
• Leprosy
• Taiwanese
• Resistance

Host factors play an important role in determining the immune response and development of leprosy. The human leukocyte antigen system (HLA) has repeatedly been found to be associated with the pathogenesis of leprosy. This study analyzes the polymorphism of the HLA class land II antigens in multibacillary leprosy patients and a healthy control group to provide predictable prognostic indicators and/or a differential diagnostic for the disease. Sixty-5 multibacillary leprosy patients from Lo-Sheng Leprosarium and 190 healthy Taiwanese were used as cases and controls, respectively. A serologic method was initially used for HLA-A and HIA-B antigen determination, and sequence-based typing was later applied for HLA-DRB1 allele typing. Although no significant associations were found with HLA-A or HIA-B antigens, this study shows a strong HLA-DRB1*0405 association with resistance to multibacillary leprosy, supporting results previously reported in the literatures.

• 出版日期2010-7