A Magnetically Drivable Nanovehicle for Curcumin with Antioxidant Capacity and MRI Relaxation Properties

作者：Magro Massimiliano; Campos Rene; Baratella Davide; Lima Giuseppina; Hola Katerina; Divoky Clemens; Stollberger Rudolf; Malina Ondrej; Aparicio Claudia; Zoppellaro Giorgio; Zboril Radek^*; Vianello Fabio

来源：Chemistry - A European Journal, 2014, 20(37): 11913-11920.

DOI：10.1002/chem.201402820

• antioxidants
• curcumin
• electrocatalysis
• magnetic nanoparticles
• MRI contrast agents

Curcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be linked to its potent antioxidant capacity. Superparamagnetic maghemite (gamma-Fe2O3), called surface-active maghemite nanoparticles (SAMNs) were surface-modified with curcumin molecules, due to the presence of under-coordinated Fe-III atoms on the nanoparticle surface. The so-obtained curcumin-modified SAMNs (SAMN@curcumin) had a mean size of 13 +/- 4 nm. SAMN@curcumin was characterized by transmission and scanning electron microscopy, UV/Vis, FTIR, and Mossbauer spectroscopy, X-ray powder diffraction, bulk susceptibility (SQUID), and relaxometry measurements (MRI imaging). The high negative contrast proclivity of SAMN@curcumin to act as potential contrast agent in MRI screenings was also tested. Moreover, the redox properties of bound curcumin were probed by electrochemistry. SAMN@curcumin was studied in the presence of different electroactive molecules, namely hydroquinone, NADH and ferrocyanide, to assess its redox behavior. Finally, SAMN@curcumin was electrochemically probed in the presence of hydrogen peroxide, demonstrating the stability and reactivity of bound curcumin.

• 出版日期2014-9-8
• 单位Univ Estadual Paulista; 河北医科大学