A new coumarin from stem bark of Mesua hexapetala

作者：Karunakaran Thiruventhan; Ee Gwendoline Cheng Lian^*; Teh Soek Sin; Daud Shaari; Mah Siau Hui; Lim Chan Kiang; Jong Vivien Yi Mian; Awang Khalijah

来源：Natural Product Research, 2016, 30(14): 1591-1597.

DOI：10.1080/14786419.2015.1120727

• Mesua hexapetala
• coumarin
• xanthone
• anti-inflammatory

A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl) xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), betasitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate antiinflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2butenyl) xanthone (4) gave very good activity.
[GRAPHICS]
A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl) xanthone (4) were isolated from the stem bark of Mesua hexapetala (Clusiaceae). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS.

• 出版日期2016