A redox-responsive mesoporous silica based nanoplatform for in vitro tumor-specific fluorescence imaging and enhanced photodynamic therapy

作者：Yuan, Fan; Li, Jiang-Lan; Cheng, Han; Zeng, Xuan^*; Zhang, Xian-Zheng^*

来源：Biomaterials Science, 2017, 6(1): 96-100.

DOI：10.1039/c7bm00793k

• TARGETING DRUG-DELIVERY
• NANOPARTICLES
• PEPTIDE

In order to obtain an optimal therapeutic effect with minimal systemic toxicity, a redox-responsive mesoporous silica nanoparticle (MSN)-based platform modified with protoporphyrin IX (PpIX)-multifunctional peptides was synthesized as an intelligent theranostic agent carrier. This redox-responsive nanoplatform could release the theranostic agent under a glutathione stimulus, produce fluorescence recovery for tumor-specific fluorescence imaging and provide tumor-enhanced photodynamic therapy.

• 出版日期2017-1-1
• 单位武汉大学