Deltamethrin toxicity: A review of oxidative stress and metabolism

作者：Lu, Qirong; Sun, Yaqi; Ares, Irma; Anadon, Arturo^*; Martinez, Marta; Martinez-Larranaga, Maria-Rosa; Yuan, Zonghui; Wang, Xu^*; Martinez, Maria-Aranzazu

来源：ENVIRONMENTAL RESEARCH, ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, 260-281, 2019-03.

DOI：10.1016/j.envres.2018.12.045

• Deltamethrin
• Oxidative stress
• Metabolism
• Toxicity
• Signaling pathway

Deltamethrin is widely used worldwide due to its valuable insecticidal activity against pests and parasites. Increasing evidence has shown that deltamethrin causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. For the first time, this review systematically summarizes the deltamethrin toxicity mechanism from the perspective of oxidative stress, including deltamethrin-mediated oxidative damage, antioxidant status, oxidative signaling pathways and modulatory effects of antagonists, synergists and placebos on oxidative stress. Further, deltamethrin metabolism, including metabolites, metabolic enzymes and pathways and deltamethrin metabolite toxicity are discussed. This review will shed new light on deltamethrin toxicity mechanisms and provide effective strategies to ensure pest control and prevention of human and animal poisoning.

• 出版日期2019-3
• 单位华中农业大学