Systematic review of plasma-membrane ecto-ATP synthase: A new player in health and disease

作者：Federica Taurino; Antonio Gnoni^*

来源：Experimental and Molecular Pathology, 2018, 104(1): 59-70.

DOI：10.1016/j.yexmp.2017.12.006

• Ecto-ATP-synthase
• Lipid metabolism
• pH regulation
• Angiogenesis
• Extracellular ATP/ADP
• IF1

This review summarizes recent studies on plasma-membrane ecto-ATP synthase from structural and functional standpoints to possible pathophysiological roles. This review discusses significant new contributions and perspectives in the area of ecto-ATP synthase since the topic was last reviewed in 2015. Following an extensive summary of the cell types in which the ecto-ATP synthase is present, its structural and functional mechanism are discussed and physiological and pathological roles of the ecto-ATP synthase are reviewed and evaluated. Attempts to define the possible role of ecto-ATP synthase as possible target for anti-cancer and anti-obesity interventions are discussed.

• 出版日期2018-2