Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs

作者：Lehto Paula; Kortejarvi Hanna; Liimatainen Anni; Ojala Krista; Kangas Heli; Hirvonen Jouni; Tanninen Veli Pekka; Peltonen Leena^*

来源：European Journal of Pharmaceutics and Biopharmaceutics, 2011, 78(3): 531-538.

DOI：10.1016/j.ejpb.2011.02.007

• Biorelevant media
• Compartmental absorption and transit (CAT) model
• Fasted state simulated intestinal fluid (FaSSIF)
• Dissolution
• In vitro-in vivo correlation (IVIVC)
• Pharmacokinetic simulation

The usefulness of selected conventional surfactant media to enhance dissolution of BCS class II drugs similarly to fasted state simulated intestinal fluid (FaSSIF) and to predict the absorption of drugs in vivo was evaluated. Dissolution behavior of danazol (Danol (R)), spironolactone (Spiridon (R)) and N74 (phase I compound) was compared between FaSSIF, containing physiological levels of sodium taurocholate (STC) and lecithin, and dissolution media containing various concentrations of anionic surfactant, sodium lauryl sulfate (SLS) or non-ionic surfactant, polysorbate (Tween) 80. Although these media differed largely in their solubilization ability, micelle size, diffusivity and surface tension, similar dissolution enhancing levels were achieved between FaSSIF and drug-specific concentrations of conventional surfactants. The dissolution enhancement was shown, however, to be important only for danazol and N74, molecules that are characterized by high hydrophobicity. An in vivo pharmacokinetic dog study was carried out with N74. Comparison of observed plasma profiles with simulated profiles obtained using compartmental absorption and transit model (CAT) indicated that 0.1% SLS medium was the best to predict in vivo plasma profiles and pharmacokinetic parameters (C-max and AUC). This study demonstrates the potential of substituting FaSSIF with more simple and cost-effective conventional surfactant media. Use of in vivo prognostic amounts of synthetic surfactants in dissolution testing could largely assist in industrial drug development as well as in quality control purposes.

• 出版日期2011-8