Potent alpha-glucosidase inhibitors from the lichen Cladonia species from Sri Lanka

作者：Karunaratne Veranja; Thadhani Vinitha M^*; Khan Shamsun Nahar; Choudhary M Iqbal

来源：Journal of the National Science Foundation of Sri Lanka, 2014, 42(1): 95-98.

DOI：10.4038/jnsfsr.v42i1.6684

• alpha-Glucosidase inhibitory activity
• diabetes type II
• lichen metabolites
• methyl beta-orcinolcarboxylate
• methylorsellinate
• zeorin

The discovery of a-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of diabetes and other carbohydrate-mediated diseases. This study focused on the lichen Cladonia sp., which yielded three potent a-glucosidase inhibitors, namely zeorin (1), methyl alpha-orcinolcarboxylate (2) and rnethylorsellinate (3) with several fold higher inhibitory activities than those of acarbose, an antidiabetic drug used to manage type II diabetes mellitus and the standard, 1-deoxynojirimycin, Atranorin (4) and lobaric acid (5), the other two metabolites isolated from the lichen did not show any alpha-glucosidase inhibitory potential. All compounds were identified on the basis of one dimentional (1D) and two dimentional (2D) NMR spectral data and with comparison to reported data.

• 出版日期2014-3