科研之友
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摘要
Herpes simplex virus (HSV) enters cells by fusion at plasma membranes or endosomes. Cellular factors route the virus to different pathways. alpha V beta 3-integrin directs HSV to a lipid raft and acidic endosome pathway. We report that infection mediated by nectin1 plus alpha V beta 3-integrin exhibits the same characteristics as entry mediated by raft-located forms of nectin. alpha V beta 3-integrin relocalizes nectin1 to lipid rafts, independently of virus. Thus, HSV routing to the lipid raft-dependent pathway is consequent to the integrin-induced relocalization of nectin1. Inhibition by the Na+/H+ exchanger 5-(N-ethyl-N-isopropyl)amirolide suggests that alpha V beta 3-integrin overexpression favors HSV macropinocytic uptake in some cells but not in others.
- 出版日期2012-3
