Association of Immune Factors with Drug-Resistant Tuberculosis: A Case-Control Study

作者：Sun, En-Tao; Xia, Dan; Li, Ben-He; Ma, Jun; Dong, Yuan-Yuan; Ding, Shu-Shu; Chen, Bai-Feng; Wen, Yu-Feng^*

来源：MEDICAL SCIENCE MONITOR, 2017, 23: 5330-5336.

DOI：10.12659/MSM.904309

• Drug Resistance, Bacterial
• Immunity, Cellular
• Retreatment
• Tuberculosis, Pulmonary

Background: Presently, studies of factors associated with drug-resistant tuberculosis (TB) focus on patients' socio-demographic characteristics and living habits, to the exclusion of biochemical indicators, especially immune factors. This study was carried out to determine whether immune factors are associated with drug-resistant TB.
Material/Methods: A total of 227 drug-resistant pulmonary TB patients and 225 drug-susceptible pulmonary TB patients were enrolled in this study. Information on socio-demographic characteristics and biochemical indicators were obtained through their clinical records. Non-conditional logistic regression was used to analyze the association of these indicators with drug-resistant TB.
Results: There were significant differences in re-treatment, marital status, alanine aminotransferase (ALT), blood uric acid (BUA), carcino-embryonic antigen (CEA), T-spot, and CD3 and CD4 counts between the 2 groups. In multivariable analysis, re-treatment [Odds Ratio (OR)=5.290, 95% Confidence Interval [CI]=2.652-10.551); CD3 (OR=1.034, 95% CI=1.001-1.068); CD4 (OR=1.035, 95% CI=1.001-1.070) and IgM (OR=1.845, 95% CI=1.153-2.952) were associated with drug-resistant TB.
Conclusions: These results suggest the need for greater attention to re-treatment cases and immune function when treating drug-resistant TB.

• 出版日期2017-11-9
• 单位皖南医学院