科研之友
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摘要
Objectives: To explore the Magnetic resonance imaging performance and features of neuron-specific enolase (NSE) in medulloblastoma in adults. Methods: MR findings of 12 patients with medulloblastoma in adults confirmed by operation and pathology were retrospectively analyzed. The expression of neuron-specific enolase (NSE) was observed by immunohistochemistry, level of NSE in serum of patient with medulloblastoma, was detected by Elisa Kit. Results: Medulloblastoma are located in the cerebellar hemisphere, including 8 cases on the right side, left 4 cases, partial involvement of cerebellar vermis, tumor shape is irregular, cerebellar involvement at the same time, cortex and medulla, substantial part of the distribution, 7 cases of male, onset age so much as the age of 64. Most tumors typically showed slightly low signal intensity on T1WI, slightly high or isointensity signal intensity on T2WI, compared with normal gray matter of the cerebellum. The expression level of NSE in medulloblastomas group was significantly higher than those in normal human brain tissues (P < 0.01), NSE of Medulloblastoma in 12 cases shows strong positive expression, the positive expression rate were strong positive (++++). Pathology shows that the original organization under optical microscope, undifferentiated tumor cells, the nuclear spindle, forming many chrysanthemum mass of tumor cells. Some smaller, to the marrow cell differentiation. Partial differentiation for the ganglion cells. Conclusions: Cerebellar medulloblastomas in adults have some characteristic MR features, it might be discriminated from other cerebellar tumor by analyzing MRI features. NSE might be as a markers of neurological injury in medulloblastomas.
