Novel 1,10-diaza-18-crown-6 derivatives

作者：Kostyanovsky R G^*; Lyssenko K A; Nabiev O G; Kadorkina G K; Chervin I I

来源：Russian Chemical Bulletin, 2014, 63(3): 772-774.

DOI：10.1007/s11172-014-0507-9

• 1,10-diaza-18-crown-6
• 1,10-bis(methoxymethyl)-1,10-diaza-18-crown-6
• 1,10-bis(azidomethyl)-1,10-diaza-18-crown-6
• 1,10-bis(azide anion)-1,10-dihydro-1,10-diaza18-crown-6
• 1,10-bis(4,5-dimethoxycarbonyltriazalomethyl)-1,10-diaza-18-crown-6
• trimethylsilyl azide
• aminomethyl-substituted triazoles
• dimethyl acetylenedicarboxylate

Reaction of 1,10-bis(methoxymethyl)-1,10-diaza-18-crown-6 (1) with trimethylsilyl azide resulted in hitherto unknown 1,10-bis(azidomethyl)-1,10-diaza-18-crown-6 (2) and novel ionic compound 1,10-bis(azide anion)-1,10-dihydro-1,10-diaza-18-crown-6 (3). Compound 2 rnneacted with dimethyl acetylenedicarboxylate to give 1,10-bis(4,5-dimethoxycarbonyltriazolomethyl)-1,10-diaza-18-crown-6 (4). Carbamoylation of 1,10-diaza-18-crown-6 (5) with optically active alpha-phenylethyl amine yielded optically active 1,10-bis(alpha-phenylethylcarbamoyl)-1,10-diaza-18-crown-6 (6).

• 出版日期2014-3