Accuracy of F-18-FDG PET/CT for lymph node staging in non-small-cell lung cancers

作者：Liu Bao jun; Dong Jing cheng^*; Xu Chang qing; Zuo Chuan tao; Le Jing jing; Guan Yi hui; Zhao Jun; Wu Jin feng; Duan Xiao hong; Cao Yu xue

来源：Chinese Medical Journal, 2009, 122(15): 1749-1754.

DOI：10.3760/cma.j.issn.0366-6999.2009.15.006

• non-small-cell lung cancer
• radiography
• tomography
• lymph node metastasis

Background This retrospective study evaluated the diagnostic accuracy of 2-(F18)-fluoro-2-deoxy-D-glucose-positron emission tomography (F-18-FDG-PET)/computed tomography (PET/CT) in the preoperative diagnosis of metastatic mediastinal and hilar lymph node in patients with non-small-cell lung cancer (NSCLC).
Methods A total of 39 patients received preoperative F-18-FDG PET/CT and the postoperative biopsy. We compared preoperative PET/CT scan results with corresponding intraoperative histopathalogic findings in 39 NSCLC patients. The sensitivity, specificity, accuracy, positive and negative predictive value of F-18-FDG PET/CT were assessed.
Results Histopathologic examination confirmed metastasis in 57 out of the 208 excised lymph nodes; 23 of the 57 nodes were mediastinal and hilar lymph nodes. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT in the preoperative diagnosis of mediastinal lymph node metastasis in NSCLC patients were 65%, 96.8%, 92%, 78.5% and 90%, respectively.
Conclusions PET/CT scan showed good accuracy in the preoperative diagnosis of mediastinal and hilar lymph node metastasis in the patients with NSCLC. We recommend that PET/CT scanning be used as a first-line evaluation tool for tumor diagnosis, therapy evaluation and follow-up.

• 出版日期2009-8-5
• 单位复旦大学