AIM2 inhibits autophagy and IFN-beta production during M. bovis infection

作者：Liu, Chunfa; Yue, Ruichao; Yang, Yang; Cui, Yongyong; Yang, Lifeng; Zhao, Deming; Zhou, Xiangmei^*

来源：Oncotarget, 2016, 7(30): 46972-46987.

DOI：10.18632/oncotarget.10503

• M. bovis
• autophagy
• AIM2 inflammasome
• STING
• Immunology and Microbiology Section
• Immune response
• Immunity

Mycobacteria can trigger the AIM2 inflammasome, autophagy activation and type-I interferon release, which are both activated by cytosolic DNA. We have recently demonstrated that activation of the AIM2 inflammasome during M. bovis infection is the result of mycobacterial translocation into the cytosol. To elucidate the effects of inflammasome activation on autophagy, we investigated the role of the AIM2 inflammasome from macrophages infected with a virulent strain of M. bovis. The results showed that the M. bovis-induced AIM2 inflammasome activation decreases autophagy in immortalized and primary murine macrophages. This relied on the inflammasome sensor AIM2 which conjugates with cytosolic DNA to inhibit the STING-dependent pathway involved in selective autophagy and interferon-beta release in Mycobacterium-infected macrophages. These results suggest that the AIM2 cytosolic DNA sensor may conjugate competitively with cytosolic M. bovis DNA to restrict M. bovis induced STING-TBK1-dependent autophagy activation and IFN-beta secretion.

• 出版日期2016-7-26
• 单位中国农业大学; 浙江农林大学