Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy

作者：Soto Brenda L; Hank Jacquelyn A; Darjatmoko Soesiawati R; Polans Arthur S; Yanke Eric M; Rakhmilevich Alexander L; Seo Songwon; Kim KyungMann; Reisfeld Ralph A; Gillies Stephen D; Sondel Paul M^*

来源：International Immunopharmacology, 2011, 11(11): 1877-1886.

DOI：10.1016/j.intimp.2011.07.019

• Resveratrol
• Immunocytokine
• Anti-GD2 antibody
• Neuroblastoma
• hu14.18-IL2

We evaluated the anti-tumor effect of Resveratrol (RV) on M21 and NXS2 tumor cell lines and its immunosuppressive activity on human and murine immune cells to determine the potential for combining RV and immunotherapy. In vitro, concentrations of RV >= 25 mcM, inhibited cell proliferation, blocked DNA synthesis and induced Cl phase arrest in tumor and immune cells. RV at 12-50 mcM inhibited antibody dependent cell mediated cytotoxicity (ADCC) of tumor cells facilitated by the hu14.18-IL2 immunocytokine (IC). The in vivo anti-tumor and immunomodulating activity of RV given systemically were assessed in mice. Results showed that this RV regimen inhibited the growth of NXS2 tumors in vivo but did not appear to interfere with blood cell count, splenocyte or macrophage function. Thus, RV may be a candidate for combining with immunotherapy.

• 出版日期2011-11
• 单位河北医科大学