A new biphenyl and antimicrobial activity of extracts and compounds from Clusia burlemarxii

作者：Ribeiro Paulo R; Ferraz Caline G; Guedes Maria L S; Martins Dirceu; Cruz Frederico G^*

来源：Fitoterapia, 2011, 82(8): 1237-1240.

DOI：10.1016/j.fitote.2011.08.012

• Clusiaceae
• Clusia burlernarxii
• Biphenyl
• Antimicrobial activity

Phytochemical investigation on Clusia burlemarxii (Clusiaceae) led to isolation and identification of nine compounds. Were isolated from leaves 3-O-alpha-L- rhamnopyranosylquercetin, 3-O-alpha-L-rhamnopyranosylkaempferol, 4-hydroxy-5,5-dimethyldihydrofuran-2-one, 2Z-delta-tocotrienoloic acid and friedelin and were isolated from trunk betulinic acid, protocatechuic acid, lyoniresinol, and a new biphenyl 2,2-dimethyl-3,5-dihydroxy-7-(4-hydroxyphenyl)chromane. The structures were determined by (1)H, (13)C-NMR, DEPT, HMBC, HMQC, HRESIMS. The Minimal Inhibitory Concentration against Streptococcus mutans, Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Escherichia coli, Salmonella choleraesuis, Pseudomonas aeruginosa, Aspergillus niger and Cladosporium cladosporioides was also determined. Extracts and compounds showed significant activity against tested Gram-positive bacteria, none activity against tested Gram-negative bacteria and fungi.

• 出版日期2011-12