Evaluation of HIV-Leishmania co-infection in patients from the northwestern Paran芍 State, Brazil = Avalia o da co-infec o HIV-Leishmania em pacientes da regi o noroeste do Estado do Paran芍, Brasil

作者：elide Aparecida Oliveira; Fernanda Almeida Celidnio; Thais Gomes Verzignassi Silveira; Maria Valdrinez Campana Lonardoni

来源：Acta Scientiarum - Health Sciences, 2011.

• american cutaneous leishmaniasis
• HIV
• co-infection
• polymerase chain reaction
• leishmaniose tegumentar americana
• HIV
• co-infec o
• rea o em cadeia da polimerase

Leishmaniasis occurs throughout the world and is one of the opportunistic infections that attack HIV-infected individuals. Few data are available on American cutaneous leishmaniasis (ACL) in HIV-infected patients. Current research investigates the occurrence ofHIV-Leishmania co-infection in HIV-infected individuals in an endemic region in Southern of Brazil. A non-randomized transversal investigation, molecular and serum epidemiologic type, on the occurrence of ACL in 169 HIV-infected patients was undertaken. The patients were followed up at the Integrated Nucleus of Health of the city Maring芍, Southern of Brazil. Results showed that 13 (7.7%) of the HIV-infected patients also presented Leishmania (Viannia) DNA, detectable in blood by PCR. Serology, direct research, culture and PCR in skin material produced negative results. PCR positiveness for Leishmania was not associated with CD4 T lymphocytes count, opportunistic disease, treatment, use of proteases inhibitors, tattooing/piercing or use of injectable drugs, residential environment or previous ACL history. Results show that HIVinfected patients who live in endemic areas may reveal Leishmania DNA in the blood without any ACL symptoms. Above findings may be attributed to anti-retrovirus medicine that controls viral replication and maintains the functionality of the immune system and to a possible anti- Leishmania activity of these drugs. As leishmanioses ocorrem em todo o mundo e s o infec es oportunistas que afetam indiv赤duos portadores do v赤rus HIV. Este estudo investigou a ocorr那ncia da co-infec o HIV-Leishmania em portadores do HIV numa regi o end那mica para LTA do Sul do Brasil. Foi realizado estudo transversal, n o randomizado, utilizando metodologia molecular e sorol車gica, sobre a ocorr那ncia de LTA em 169 portadores do HIV. Foram estudados pacientes atendidos no N迆cleo Integrado de Sa迆de de Maring芍, Paran芍, Sul do Brasil. Observou-se que 13 (7,7%) dos pacientes infectados pelo HIV tamb谷m apresentavam o DNA de Leishmania (Viannia), detect芍vel no sangue por PCR. A sorologia, pesquisa direta de Leishmania, cultura e PCR de les es de pele foram negativas. A positividade da PCR n o estava associada 角 contagem de linf車citos T CD4+, doen a oportunista, tratamento, uso de inibidores de protease, tatuagem, uso de drogas injet芍veis, ambiente da resid那ncia ou hist車ria pr谷via de LTA. Os resultados mostraram que indiv赤duos portadores do v赤rus HIV que residem em 芍rea end那mica podem apresentar o DNA de Leishmania sem manifestar sintomas de LTA. Estes resultados podem ser atribu赤dos a a o dos medicamentos an

• 出版日期2011