A New Cycloartane Glucoside from Rhizophora stylosa

作者：Phan Thi Thanh Huong; Chau Ngoc Diep; Nguyen Van Thanh; Vu Anh Tu; Tran Hong Hanh; Nguyen The Cuong; Nguyen Phuong Thao; Nguyen Xuan Cuong; Do Thi Thao; Tran Huy Thai; Nguyen Hoai Nam; Ninh Khac Ban; Phan Van Kiem; Chau Van Minh^*

来源：Natural Product Communications, 2014, 9(9): 1255-1257.

DOI：10.1177/1934578x1400900909

• Rhizophora stylosa
• Rhizophoraceae
• Cycloartane
• Rhizostyloside
• Cytotoxic activity
• Caspase-3/7

Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (H-1 and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, NOESY) and HR-BSI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.

• 出版日期2014-9