Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus

作者：Wang, Fenghua; Chen, Cheng; Yang, Kailin; Xu, Yang; Liu, Xiaomei; Gao, Fan; Liu, He; Chen, Xia; Zhao, Qi; Liu, Xiang; Cai, Yan; Yang, Haitao^*

来源：Journal of Medicinal Chemistry, 2017, 60(7): 3212-3216.

DOI：10.1021/acs.jmedchem.7b00103

• HUMAN CORONAVIRUS

Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (M-pro) plays an essential role in viral replication. We solved the structure of PEDV complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing atomic level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV M-pro. These compounds have potential as future therapeutics to combat PEDV infection.

• 出版日期2017-4-13
• 单位天津大学