Antifungal activity of cinnamaldehyde and eugenol congeners against wood-rot fungi

作者：Cheng Sen Sung; Liu Ju Yun; Chang Ed Haun; Chang Shang Tzen^*

来源：Bioresource Technology, 2008, 99(11): 5145-5149.

DOI：10.1016/j.biortech.2007.09.013

• antifungal activity
• cinnamaldehyde
• eugenol
• Laetiporus sulphureus
• Lenzites betulina

In this study, the antifungal activities of cinnamaldehyde and eugenol congeners against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus were evaluated and the relationships between the antifungal activity and the chemical structures were also examined. Results from antifungal tests revealed that cinnamaldehyde, alpha-methyl cinnamaldehyde, (E)-2-methylcinnamic acid, eugenol and isoeugenol exhibited strong antifungal activity against all fungi tested. Results derived from the chemical structure-antifungal activity relationship study suggested that compounds with an aldehyde group or an acid group, a conjugated double bond and a length of CH chain outside the ring affect their antifungal properties. Furthermore, the presence of the methyl moiety in the ortho position may have a considerable influence on the inhibitory action against L. betulina and L. sulphureus. In addition, the lipophilicity may play, in part, a crucial role in determining the toxicity of phenylpropenes.

• 出版日期2008-7