A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification

作者：Arebro Julia; Ekstedt Sandra; Hjalmarsson Eric; Winqvist Ola; Georen Susanna Kumlien; Cardell Lars Olaf^*

来源：Scientific Reports, 2017, 7(1): 43568.

DOI：10.1038/srep43568

A re-examination of former concepts is required to meet today's medical challenges in allergic rhinitis. Previously, neutrophils have been treated as a relatively homogenous cell population found in the nose both when the patient is suffering at the height of the allergic season as well as when the patient report no symptoms. However, new data indicates that neutrophils can be divided into different subsets with diverse roles in inflammation. We showed increased levels of neutrophils in peripheral blood, nasal biopsies and nasal lavage fluid (NAL) from allergic patients during the pollen season compared to healthy controls. A closer examination revealed that the activated subset of neutrophils, CD16(high) CD62L(dim), outweighed the normal form CD16high CD62L(high) in nasal tissue among these patients. This skewed distribution was not seen in controls. The normal subset prevailed in peripheral blood from patients as well as controls, whereas CD16high CD62L(dim) and CD16(dim) CD62L(dim) subsets, the latter considered "end state" neutrophils before apoptosis, were elevated in NAL. Functional in vitro experiments revealed that activated neutrophils exhibit a T cell priming capacity and an ability to enhance eosinophil migration. Activated neutrophils may thus contribute to allergic inflammation seen in allergic rhinitis by priming T cells and attracting eosinophils.

• 出版日期2017-3-8