A new semisynthetic ocotillol-type saponin and resuscitation of haemorrhagic shock

作者：Liu J P; Lu D; Zhao Y; Li P Y^*; Li X

来源：Journal of Asian Natural Products Research, 2007, 9(2): 103-113.

DOI：10.1080/10286020500251741

• haemorrhagic shock
• ocotillol-type saponin
• resuscitation
• semisynthesis
• 3-O-[beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl]-dammar-20S,24S-e poxy-3 beta,12 beta,25-triol
• haemorrhagic shock

A new ocotillol-type saponin (PGQ) has been semisynthesised from 20(S)-ginsenoside Rg3 for the first time, in with a yield of 73%, by oxidation and cyclisation of the side-chain. Its structure was characterised by IR, HR-MS, (HNMR)-H-1, C-13 NMR, H-1-H-1 COSY, DEPT, HMBC and HMQC spectroscopy as 3-O-[beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl]-damniar- 20S,24S-epoxy-3 beta,12 beta,25-triol (1). The saponin produced a beneficial effect on resuscitation of haemorrhagic shock as follows: first, it could significantly rise increased mean arterial pressure; second, it could increased blood oxygen content; third, it could markedly decreased serum lipoperoxidase and increased superoxide dismutase (SOD) activities. Thus, the saponin had the effect of an anti-haemorrhagic shock.

• 出版日期2007-3
• 单位沈阳药科大学; 吉林大学