MRI of Frozen Tissue Demonstrates a Phase Shift

作者：Lu Aiming^*; Daniel Bruce L; Kaye Elena; Pauly Kim Butts

来源：Magnetic Resonance in Medicine, 2011, 66(6): 1582-1589.

DOI：10.1002/mrm.22953

• temperature monitoring
• cryoablation
• phase shift
• ultra-short TE imaging
• intervention

While temperature mapping is desired during cryosurgery for prostate cancer treatment, an effective approach for this purpose is still needed. We have demonstrated a phase shift with temperature in our in vivo canine experiments and ex vivo tissue sample experiments within the frozen tissue. The phase shift is much larger (similar to 0.7 degrees/degrees C with an echo time of 0.1 ms at 0.5 T) in magnitude than that predicted by conventional proton resonant frequency shift (0.008 degrees/degrees C). It shows little dependence on the echo times used and thus is not due to a frequency change, although frequency-dependent phase shift has been observed near the frozen tissue. This phase shift varies monotonically with temperature within the frozen tissue and therefore may be potentially used as a novel temperature mapping approach in cryoablation applications. Magn Reson Med 66:1582-1589, 2011.

• 出版日期2011-12