Antibody-drug conjugates: an emerging modality for the treatment of cancer

作者：Leal Mauricio^*; Sapra Puja; Hurvitz Sara A; Senter Peter; Wahl Alan; Schutten Melissa; Shah Dhaval K; Haddish Berhane Nahor; Kabbarah Omar

来源：Annals of the New York Academy of Sciences, 2014, 1321(1): 41-54.

DOI：10.1111/nyas.12499

• antibody-drug conjugate
• linker
• payload
• quantitative translational systems pharmacology
• cancer therapy

Antibody-drug conjugates (ADCs) offer promise as a therapeutic modality that can potentially reduce the toxicities and poor therapeutic indices caused by the lack of specificity of conventional anticancer therapies. ADCs combine the potency of cytotoxic agents with the target selectivity of antibodies by chemically linking a cytotoxic payload to an antibody, potentially creating a synthetic molecule that will deliver targeted antitumor therapy that is both safe and efficacious. The ADC repertoire contains a range of payload molecules, antibodies, and linkers. Two ADC molecules, Kadcyla (R) and Adcetris (R), have been approved by the FDA, and many more are currently in clinical development.

• 出版日期2014