Acrylamide Polymer Double-Network Hydrogels: Candidate Cartilage Repair Materials with Cartilage-Like Dynamic Stiffness and Attractive Surgery-Related Attachment Mechanics

作者：Arnold Markus P^*; Daniels Alma U; Ronken Sarah; Ardura Garcia Helena; Friederich Niklaus F; Kurokawa Takayuki; Gong Jian P; Wirz Dieter

来源：Cartilage, 2011, 2(4): 374-383.

DOI：10.1177/1947603511402320

• gels
• modulus
• loss angle
• cartilage repair
• suturing

Background: In focal repair of joint cartilage and meniscus, initial stiffness and strength of repairs are generally much less than surrounding tissue. This increases early failure potential. Secure primary fixation of the repair material is also a problem. Acrylamide polymer double-network (DN) hydrogels are candidate-improved repair materials. DN gels have exceptional strength and toughness compared to ordinary gels. This stems from the double-network structure in which there is a high molar ratio of the second network to the first network, with the first network highly crosslinked and the second loosely crosslinked. Previous studies of acrylic PAMPS/PDMAAm and PAMPS/PAAm DN gels demonstrated physicochemical stability and tissue compatibility as well as the ability to foster cartilage formation. Methods: Mechanical properties related to surgical use were tested in 2 types of DN gels. Results: Remarkably, these >90%-water DN gels exhibited dynamic impact stiffness (E*) values (similar to 1.1 and similar to 1.5 MPa) approaching swine meniscus (similar to 2.9 MPa). Dynamic impact energy-absorbing capability was much lower (median loss angles of similar to 2 degrees) than swine meniscus (>10 degrees), but it is intriguing that >90%-water materials can efficiently store energy. Also, fine 4/0 suture tear-out strength approached cartilage (similar to 2.1 and similar to 7.1 N v. similar to 13.5 N). Initial strength of attachment of DN gels to cartilage with acrylic tissue adhesive was also high (similar to 0.20 and similar to 0.15 N/mm(2)). Conclusions: DN gel strength and toughness properties stem from optimized entanglement of the 2 network components. DN gels thus have obvious structural parallels with cartilaginous tissues, and their surgical handling properties make them ideal candidates for clinical use.

• 出版日期2011-10