Embryo aneuploidy and the role of morphological and genetic screening

作者：Wells Dagan^*

来源：Reproductive BioMedicine Online, 2010, 21(3): 274-277.

DOI：10.1016/j.rbmo.2010.06.035

• aneuploidy
• chromosome
• embryo
• morphology
• preimplantation genetic diagnosis
• preimplantation genetic screening

Chromosome abnormalities are common among human oocytes and are usually lethal to any embryos they produce. It therefore seems logical that a reliable technique for distinguishing between normal and aneuploid embryos would be a useful tool for physicians and embryologists, assisting the choice of which embryo(s) to prioritize for uterine transfer. This concept has led to the development of a variety of methods for the detection of chromosome abnormalities in oocytes and embryos, most often referred to as preimplantation genetic screening (PGS). However, several well-controlled studies have been unable to show an advantage of chromosome screening in terms of pregnancy and birth rates. Some investigators have suggested that damage to embryos, sustained during cleavage-stage biopsy, might explain why PGS has not always provided the anticipated benefits. This paper asks whether there is evidence that a non-invasive, morphological analysis could allow chromosomally normal embryos to be accurately identified and reviews data from the most recent publication concerning IVF outcome following PGS.

• 出版日期2010-9