Health assessment of gasoline and fuel oxygenate vapors: Developmental toxicity in mice

作者：Roberts L G; Gray T M; Marr M C; Tyl R W; Trimmer G W; Hoffman G M; Murray F J; Clark C R^*; Schreiner C A

来源：Regulatory Toxicology and Pharmacology, 2014, 70(2): S58-S68.

DOI：10.1016/j.yrtph.2014.06.011

• Developmental toxicity
• Gasoline vapor condensates
• Methyl tertiary butyl ether (MTBE)
• Fuel oxygenates
• Evaporative emissions
• Gastroschisis
• Ectopia cordis

CD-1 mice were exposed to baseline gasoline vapor condensate (BGVC) alone or to vapors of gasoline blended with methyl tertiary butyl ether (G/MTBE). Inhalation exposures were 6 h/d on GD 5-17 at levels of 0, 2000, 10,000, and 20,000 mg/m(3). Darns were evaluated for evidence of maternal toxicity, and fetuses were weighed, sexed, and evaluated for external, visceral, and skeletal anomalies. Exposure to 20,000 mg/m(3) of BGVC produced slight reductions in maternal body weight/gain and decreased fetal body weight. G/MTBE exposure did not produce statistically significant maternal or developmental effects; however, two uncommon ventral wall closure defects occurred: gastroschisis (1 fetus at 10,000 mg/m(3)) and ectopia cordis (1 fetus at 2000 mg/m(3); 2 fetuses/I litter at 10,000 mg/m(3)). A second study (G/MTBE-2) evaluated similar exposure levels on GD 5-16 and an additional group exposed to 30,000 mg/m(3) from GD 5-10. An increased incidence of cleft palate was observed at 30,000 mg/m3 G/MTBE. No ectopia cordis occurred in the replicate study, but a single observation of gastroschisis was observed at 30,000 mg/m(3). The no observed adverse effect levels for maternal/developmental toxicity in the BGVC study were 10,000/2000 mg/m(3), 20,000/20,000 for the G/MTBE study, and 10,000/20,000 for the G/MTBE-2 study.

• 出版日期2014-11-1