MR-guided laser-induced thermotherapy (LITT) in patients with liver metastases of uveal melanoma

作者：Eichler K^*; Zangos S; Gruber Rouh T; Vogl T J; Mack M G

来源：Journal of the European Academy of Dermatology and Venereology, 2014, 28(12): 1756-1760.

DOI：10.1111/jdv.12405

PurposeEvaluation of the local tumour control rate and survival data for magnetic resonance (MR) imaging-guided laser ablation of uveal malignant melanoma liver metastases by using laser-induced interstitial thermotherapy (LITT). %26lt;br%26gt;Materials and methodsThe LITT was performed in 18 patients with liver metastases (n=44) from uveal malignant melanoma. All patients tolerated this intervention well. With the Kaplan-Meier method, the survival rates were calculated. Indications for the procedure were defined for patients with no more than five metastases, none of which were larger than 5cm in diameter: The Indication for LITT treatment were recurrent liver metastases after partial liver resection (22%), locally non-resectable tumours (17%) or metastases in both liver lobes (61%). %26lt;br%26gt;ResultsThe mean survival rate for all treated patients was 3.6years (95% CI: 2.19, 5.06). We started the calculation on the date of diagnosis of the metastases treated with LITT. The median survival was 1.83years; 1-year survival, 88%; 3-year survival 47%, 5-year survival 17%. Calculated after the first LITT treatment the median survival was 2.8years (95% CI: 1.0, 5.0). 10 patients were treated by transarterial chemoembolization before LITT. %26lt;br%26gt;ConclusionMR-guided LITT treatment shows a high local tumour control and survival rates in patients with liver metastases of uveal malignant melanoma.

• 出版日期2014-12