Association between gestational diabetes and biomarkers: a role in diagnosis

作者：Adam Sumaiya^*; Pheiffer Carmen; Dias Stephanie; Rheeder Paul

来源：Biomarkers, 2018, 23(4): 386-391.

DOI：10.1080/1354750X.2018.1432690

• Biomarkers
• gestational diabetes
• adiponectin
• insulin

Background: We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM.Methods: In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM.Results: Of the 262 pregnant women, 83 (31.7%) had GDM. Women with GDM were heavier (p=0.04) and had more clinical risk factors (p=0.008). We found a significant difference in fasting insulin (p<0.001), adiponectin (p=0.046), HOMA (p<0.001) and QUICKI (p<0.001). HOMA (AUROC=0.82) or QUICKI (AUROC=0.82) improved the ability of risk factors to identify women at high risk of GDM.Conclusions: Insulin sensitivity markers are promising tools to identify women at high risk of GDM.

• 出版日期2018