A Practical Preparation of Highly Versatile N-Acylpyrroles from 2,4,4-Trimethoxybutan-1-amine

作者：Maehara Tomoaki; Kanno Rentaro; Yokoshima Satoshi; Fukuyama Tohru^*

来源：Organic Letters, 2012, 14(7): 1946-1948.

DOI：10.1021/ol3005613

A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1-amine, followed by acid-mediated cyclization to form the pyrrole ring. The preparative procedure is highly tolerant of a variety of functional groups.

• 出版日期2012-4-6