A meta-analysis of extracorporeal membrane oxygenation for acute respiratory distress syndrome

作者：Xia Fei; Pei Zeng-Song; Fu Jiang-Quan; Zheng Xiao-Han; Shen Zi-Xuan; Ma Hua-Xing; Li Hai-Bing; Xing Chun-Gen^*; Guo Hui^*

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(1): 69-75.

• Extracorporeal membrane oxygenation
• acute respiratory distress
• mechanical ventilation
• meta-analysis

Objective: Extracorporeal membrane oxygenation (ECMO) is an important rescue therapy for patients with severe lung failure. A meta-analysis was conducted to investigate the effect difference between ECMO and the conventional mechanical ventilation for acute respiratory distress syndrome (ARDS). Methods: Relevant studies on ECMO and ARDS were ascertained by retrieving PubMed, EMBASE, Web of Science and EBSCO databases until April, 2017. The odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated to evaluate the mortality rate. Results: Thirteen studies with a total of 628 patients and 795 controls were included in this metaanalysis. The results demonstrated that there was no significant effect difference between ECMO and conventional mechanical ventilation in the treatment of ARDS, and the odds ratio was 1.12 (95% CI: 0.69 to 1.81, random effect model). However, we found that the mortality rate of ECMO group was lower than control group in the Chinese subgroup with OR at 0.39 (95% CI: 0.17 to 0.86, fixed effect model). No significant publication bias was found in current study. Conclusions: Except for mortality rates of certain Chinese patients, there was no significant effect difference between ECMO and conventional mechanical ventilation in the treatment of patients with ARDs. A more comprehensive assessment of major factors is needed to evaluate the mortality rate of ARDS after ECMO treatment.

• 出版日期2018
• 单位苏州大学