Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20

作者：Abarzua Sibylle^*; Serikawa Tatsuo; Szewczyk Marlen; Richter Dagmar Ulrike; Piechulla Birgit; Briese Volker

来源：Archives of Gynecology and Obstetrics, 2012, 285(4): 1145-1151.

DOI：10.1007/s00404-011-2120-6

• Lignans
• Cell proliferation
• MCF 7
• BT 20

Phytoestrogens are plant-derived, non-steroidal phytochemicals with anticarcinogenic potential. The major structural classes are the isoflavones and lignans. The aim of this study was to compare the effect of the plant-derived lignans secoisolariciresinol and matairesinol with the human lignans enterodiol and enterolactone as well as with 17 beta estradiol and tamoxifen on cell proliferation of breast carcinoma cell lines. %26lt;br%26gt;The influence of the lignans, 17 beta estradiol and tamoxifen on cell proliferation was determined using the BrdU test in MCF 7 and BT 20 cell lines. %26lt;br%26gt;Enterodiol and enterolactone induced a stronger inhibition of cell growth in MCF 7 and BT 20 cells than secoisolariciresinol and matairesinol. The inhibition effects were less expressed in the BT 20 than in the MCF 7 cells. %26lt;br%26gt;The human lignans enterodiol and enterolactone are more biologically active than their precursors secoisolariciresinol and matairesinol, and may be defined as the real drugs in cancer prevention.

• 出版日期2012-4