New phosphine oxide aziridinyl phosphonates as chiral Lewis bases for the Abramov-type phosphonylation of aldehydes

作者：Dogan Ozdemir^*; Isci Muhammet; Aygun Muhittin

来源：Tetrahedron: Asymmetry , 2013, 24(9-10): 562-567.

DOI：10.1016/j.tetasy.2013.04.005

A series of Lewis bases were screened for Abramov-type phosphine additions to aldehydes. A novel phosphine oxide aziridinyl phosphonate POAP-A was found to be better than the others in forming the product in 96% yield and with 42% ee. The absolute configuration of the newly synthesized POAP Lewis bases was determined by single-crystal X-ray analysis.

• 出版日期2013-5-31