Phase I study of autologous dendritic cell tumor vaccine in patients with non-small cell lung cancer

作者：Um Soo Jung; Choi Young Jin; Shin Ho Jin; Son Cheol Hun; Park You Soo; Roh Mee Sook; Kim Yun Seong; Kim Young Dae; Lee Soo Keol; Jung Min Ho; Lee Min Ki; Son Choonhee; Choi Pil Jo; Chung Jooseop; Kang Chi Dug; Lee Eun Yup

来源：Lung Cancer, 2010, 70(2): 188-194.

DOI：10.1016/j.lungcan.2010.02.006

• Dendritic cells
• Electroporation
• Immunotherapy
• Non-small cell lung carcinoma
• Tumor vaccines

Background: A dendritic cell vaccine has been developed as a novel strategy for generating antitumor immunity in the treatment of cancer. The purpose of this study was to assess the maximal tolerated dose, safety, and immunologic response of a new dendritic cell vaccine (DC-Vac) into which tumor lysate was loaded by electroporation and pulse in patients with advanced non-small cell lung cancer (NSCLC).
Patients and methods: Fifteen patients with inoperable stage III or IV NSCLC were assigned to cohorts that received 3, 6, or 12 x 10(6) DC-Vac intradermally 3 times at 2 week intervals. We also evaluated immunologic and tumor responses.
Results: The maximum dose of DC-Vac (12 x 10(6)) was shown to be safe. In 5 of 9 patients, the vaccine resulted in increased interferon (IFN)-gamma production by CD8+ cells after exposure to tumor lysate. Additionally, there were mixed responses which do fulfill progressive disease definition but demonstrate some clinical benefit in two patients.
Conclusion: The administration of tumor lysate-loaded autologous dendritic cells by electroporation and pulse was non-toxic and induced immunologic responses to tumor antigens. The two mixed tumor responses which were achieved may represent a potential benefit of this new DC-Vac.

• 出版日期2010-11