Neurochemical correlation between major depressive disorder and neurodegenerative diseases

作者：Reus Gislaine Z; Titus Stephanie E; Abelaira Helena M; Freitas Sharon M; Tuon Talita; Quevedo Joao; Budni Josiane

来源：Life Sciences, 2016, 158: 121-129.

DOI：10.1016/j.lfs.2016.06.027

• Alzheimer's disease
• Huntington's disease
• Amyotrophic Lateral Sclerosis
• Parkinson's disease
• Aging
• Major depressive disorder

Major depressive disorder (MDD) is one of the most prevalent and life-threatening forms of mental illnesses affecting elderly people and has been associated with poor cognitive function. Recent evidence suggests a strong relationship between MDD and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS), as well as natural processes of aging. Changes in the neuroplasticity, morphology, and neurotransmission in the brain are seem to be associated to both, MDD and neurodegenerative diseases. In addition, there is evidence that psychological stress and MDD are associated with molecular and cellular signs of accelerated aging. This review will highlight the relationship between MDD, the aging process, and neurodegenerative diseases, emphasizing the neurochemical processes involved.

• 出版日期2016-8-1