Association of serum omentin-1 levels with coronary artery disease

作者：Zhong Xia; Zhang Hai yang; Tan Hui; Zhou Yi; Liu Fu li; Chen Fu qin^*; Shang De ya

来源：Acta Pharmacologica Sinica, 2011, 32(7): 873-878.

DOI：10.1038/aps.2011.26

• coronary artery disease
• acute coronary syndrome
• adipokines
• omentin-1
• interleukin-6

Aim: Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. Decreased omentin-1 expression has been found in many chronic inflammatory diseases. However, the role of omentin-1 in coronary artery disease (CAD) has not been elucidated. The aim of the present study was to determine whether serum concentration of omentin-1 was independently associated with CAD.
Methods: One hundred and fifty five patients with CAD were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). A total of 52 healthy participants served as controls. Serum concentrations of omentin-1 and interleukin-6 (IL-6) were measured using ELISA. The association of omentin-1 with CAD and cardiovascular disease risk factors was evaluated.
Results: Serum omentin-1 levels were lower in patients with ACS or SAP compared with controls (ACS, 113.08 +/- 61.43 ng/mL; SAP, 155.41 +/- 66.89 ng/mL; control, 254.00 +/- 72.9 ng/mL; P < 0.01). Patients with ACS also had lower serum concentrations of omentin-1 compared with patients with SAP (P < 0.01). Serum concentration of omentin-1 was negatively correlated with body mass index (r=-0.17, P < 0.05) and serum IL-6 concentration (r=-0.19, P < 0.05). Furthermore, multiple logistic regression analysis showed that serum omentin-1 concentrations were independently correlated with CAD.
Conclusion: The findings suggest that serum concentrations of omentin-1 are related to CAD.

• 出版日期2011-7
• 单位山东大学