A new drug delivery system for Mitomycin C to improve intravesical instillation

作者：Sun, Xiaoliang; Sun, Peng; Li, Bo; Liu, Yiqing; Wang, Muwen; Suo, Ning; Yang, Min; Zhang, Dong^*; Jin, Xunbo^*

来源：Materials and Design, 2016, 110: 849-857.

DOI：10.1016/j.matdes.2016.08.058

• Drug delivery system
• Mitomycin C
• Intravesical instillation
• In situ forming depot
• Sustained release
• Apoptosis

The conventional administration of Mitomycin C (MMC) in intravesical instillations has its limitations. In this study, MMC was loaded onto an in situ forming depot consisting of chitosan (CS), p-glycerophosphate (GP) and Fe3O4 magnetic nanoparticles (Fe3O4-MNPs) to improve its effects. The features and effects of this new drug delivery mode were investigated. The new drug delivery system (Fe3O4-MMC-CS/GP) exhibited superior sol-gel transformation and magnetism. Sustained release of MMC was observed both in vitro and in vivo, and the retention, which lasted for 72 h in the rat bladder, was further examined using frozen sections. The Cell Counting Kit-8 (CCK-8) and flow cytometry assays revealed better anti-tumor activity of Fe304-MMC-CS/GP compared with the free MMC solution. Animal experiments showed that Fe3O4-MMC-CS/GP provided a favorable survival rate and inhibited the growth of bladder tumors. Moreover, this drug delivery system enhanced tumor cell apoptosis compared with the conventional route of MMC administration in rats.

• 出版日期2016-11-15
• 单位山东省立医院; 山东大学