An Elevated High-Sensitivity C-Reactive Protein Level Is Associated with Unfavorable Functional Outcomes of Small-Artery Occlusion in Patients without Diabetes.

作者：Gao, Yuan; Liu, Ji; Wang, Wanjun; Gao, Chunlin; Yu, Changshen; Liu, Shoufeng; Wu, Jialing

来源：European Neurology, 2017, 78(1-2): 48-55.

DOI：10.1159/000477929

• C-reactive protein
• Diabetes
• Outcome
• Small artery occlusion
• Stroke

BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is associated with a risk of causing diabetes mellitus and ischemic stroke. However, the association between hs-CRP levels and functional outcome after small-artery occlusion (SAO) is unknown. METHODS: Data for 836 patients diagnosed with SAO were collected from the Department of Neurorehabilitation of Huanhu Hospital. Hs-CRP values were classi fi ed according to quartiles (<0.67, 0.67 to <1.46, 1.46 to <3.46, and >/=3.46 mg/L). We examined the relationship between hs-CRP levels on admission and modified Rankin Scale (mRS) scores using univariate and multivariate analyses. We further performed subgroup analyses of patients with and without diabetes. RESULTS: Patients in the highest hs-CRP quartile had a significantly higher risk of an unfavorable outcome. In the non-diabetes subgroup, the elevated hs-CRP quartiles were associated with higher mRS scores. In the diabetes subgroup, no statistically significant association was observed between hs-CRP levels and mRS. CONCLUSIONS: Elevated hs-CRP level on admission was associated with a poor functional outcome 3 months after SAO, especially among nondiabetes patients. However, no significant associations were observed in patients with diabetes.

• 出版日期2017
• 单位天津市环湖医院