Association between TNF-alpha and IL-1 beta genotypes vs Helicobacter pylori infection in Indonesia

作者：Zhao Yang; Wang Jing Wen; Tanaka Tsutomu; Hosono Akihiro; Ando Ryosuke; Tokudome Shinkan; Soeripto; Triningsih F X Ediati; Triono Tegu; Sumoharjo Suwignyo; Achwan E Y Wenny Astuti; Gunawan Stephanus; Li Yu Min^*

来源：World Journal of Gastroenterology, 2013, 19(46): 8758-8763.

DOI：10.3748/wjg.v19.i46.8758

• Helicobacter pylori
• Tumor necrosis factor
• Interleukin-1 beta
• Infection
• Allele

AIM: To investigate the correlation between the Helicobacter pylori (H. pylori) infection and host genetic background of healthy populations in Indonesia. %26lt;br%26gt;METHODS: In March 2007, epidemiological studies were undertaken on the general population of a city in Indonesia (Mataram, Lombok). The participants included 107 men and 187 women, whose ages ranged from 6 to 74 years old, with an average age of 34.0 (+/- 14.4) (+/- SD). The H. pylori of subject by UBT method determination, and through the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method parsing the single nucleotide polymorphism of interleukin (IL)-8, IL-4, IL-1 beta, CD14, tumor necrosis factor (TNF-alpha) and tyrosine-protein phosphates non-receptor type 11 (PTPN11) genotypes. The experimental data were analyzed by the statistical software SAS. %26lt;br%26gt;RESULTS: The H. pylori infection rates in the healthy Indonesian population studied were 8.4% for men and 12.8% for women; no obvious differences were noted for H. pylori infection rates by sex or age. TC genotypes of IL-4, TC and CC genotypes of TNF-alpha, and GA genotypes of PTPN11, were higher in frequency. Both CC and TC genotype of TNF-alpha T-1031C loci featured higher expressions in the healthy Indonesian population Indonesia studied of (OR = 1.99; 95%CI: 0.67-5.89) and (OR = 1.66; 95%CI: 0.73-3.76), respectively. C allele of IL-1 beta T-31C gene locus was at a higher risk (OR = 1.11; 95%CI: 0.70-1.73) of H. pylori infection, but no statistical significance was found in our study. %26lt;br%26gt;CONCLUSION: We reveal that the association between the TNF-alpha and IL-1 beta genotypes may be the susceptibility of H. pylori in the studied population.

• 出版日期2013-12-14
• 单位兰州大学