Microbial transformation of cycloastragenol

作者：Kuban Melis; Ongen Gaye; Khan Ikhlas A; Bedir Erdal^*

来源：Phytochemistry, 2013, 88: 99-104.

DOI：10.1016/j.phytochem.2012.12.007

• Astragalus
• Cycloastragenol
• Biotransformation
• Cunninghamella blakesleeana NRRL 1369
• Glomerella fusarioides ATCC 9552
• Mycobacterium sp NRRL 3805

The microbial transformation of cycloastragenol by the fungi Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552, and the bacterium Mycobacterium sp. NRRL 3805 were investigated. Both fungi mainly provided hydroxylated metabolites together with products formed by cyclization, dehydrogenation and Baeyer-Villiger oxidation resulting in a ring cleavage. The bacteria yielded only a single oxidation product, namely, 3-oxo-cycloastragenol. Structures of the metabolites were elucidated by 1-D (H-1,C-13), 2-D NMR (COSY, HMBC, HMQC) and HRMS analyses.

• 出版日期2013-4