Muscling In on PGC-1 alpha for Improved Quality of Life in ALS

作者:Johri Ashu*; Beal M Flint
来源:Cell Metabolism, 2012, 15(5): 567-569.
DOI:10.1016/j.cmet.2012.04.015

摘要

Impaired activity of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1 alpha activity in muscle in a mouse model of amyotrophic lateral sclerosis.

  • 出版日期2012-5-2