Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes

作者：Wang Yanzhao; Ye Longwu; Zhang Liming^*

来源：Chemical communications, 2011, 47(27): 7815-7817.

DOI：10.1039/c1cc12212f

The first gold-catalyzed addition of N-arylhydroxylamines to aliphatic terminal alkynes is developed to access O-alkenyl-N-arylhydroxylamines, which undergo facile in situ sequential 3,3-rearrangements and cyclodehydrations to afford 2-alkylindoles with regiospecificity and under exceptionally mild reaction conditions.

• 出版日期2011