Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation

作者：Kostova Zlatka; Tsai Yien Che; Weissman Allan M^*

来源：Seminars in Cell & Developmental Biology, 2007, 18(6): 770-779.

DOI：10.1016/j.semcdb.2007.09.002

• endoplasmic reticulum-associated degradation
• ubiquitin protein ligase (E3)
• proteasome
• Saccharomyces cerevisiae

Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action. Published by Elsevier Ltd.

• 出版日期2007-12