Additive hypoglycaemic effect of nateglinide and exogenous glucagon-like peptide-1 in type 2 diabetes

作者：Bell P M^*; Cuthbertson J; Patterson S; O'Harte F P M

来源：Diabetes Research and Clinical Practice, 2011, 91(3): E68-E70.

DOI：10.1016/j.diabres.2010.11.033

• Nateglinide
• GLP-1
• Postprandial glycaemia

We examined the postprandial glucose regulators nateglinide and GLP-1, separately and in combination, in people with type 2 diabetes. Nateglinide inhibited DPP-4 activity, reduced GLP-1 degradation and enhanced its insulinotropic and blood glucose lowering effect. Combining nateglinide and GLP-1 derivatives may effectively control postprandial glycaemia.

• 出版日期2011-3