Multiple chromosomal monosomies are characteristic of giant cell ependymoma

作者：Dahlback Hanne Sofie S^*; Brandal Petter; Krossnes Bard K; Fric Radek; Meling Torstein R; Meza Zepeda Leonardo A; Danielsen Havard E; Heim Sverre

来源：Human Pathology, 2011, 42(12): 2042-2046.

DOI：10.1016/j.humpath.2011.02.012

• Giant cell ependymoma
• Anaplastic ependymoma
• Karyotyping
• Aneuploidy
• DNA ploidy analysis
• Array comparative genomic hybridization

Giant cell ependymoma, a rare ependymoma subtype, was recently recognized as a separate diagnostic entity with variations both in malignant potential and course of disease. We analyzed the first supratentorial giant cell ependymoma using G-band karyotyping, DNA ploidy analysis, and array comparative genomic hybridization. The tumor was hypodiploid, and the karyotype showed multiple monosomies. This novel cytogenetic pattern seems specific for giant cell ependymoma as the only previous cytogenetic analysis of a giant cell ependymoma found similar monosomies. We were also able to analyze cytogenetically the subsequent recurrent tumor, phenotypically an anaplastic ependymoma, allowing a first insight into the genetic events involved in disease progression.

• 出版日期2011-12
• 单位河北医科大学